ARBOCEL®
Powdered Cellulose
Introduction
ARBOCEL®, powdered cellulose, is a plant-based functional filler. Powdered cellulose is chemically inert and is thus not metabolized by the human body. Because it is not digested, it has no functional caloric value. It is commonly used by formulators as an alternative to lactose. ARBOCEL®'s binding properties and natural fiber structure lead to stable tablets with low friability.
Various grades of ARBOCEL® are available. The course granular grade, ARBOCEL® A 300 provides excellent flow and the fine, fibrous grades, M 80 and P 290, offer improved binding properties. All grades exhibit low moisture absorption, assuring good shelf life stability.
Physical Properties
- Purified, mechanically processed cellulose
- Chemically inert
- Low moisture absorption
- Fibrous structure
|
M 80
|
P 290
|
A 300
|
|
|---|---|---|---|
| Appearance |
Powder
|
Powder
|
Granules
|
| Average Particle Size* |
60 µm
|
80 µm
|
250 µm
|
| Bulk Density** |
0.22 g/ cm³
|
0.30 g/ cm³
|
0.35 g/ cm³
|
| Angle of Repose |
62
|
49
|
36
|
| Identity |
Conforms to Ph. Eur., USP/ NF, JP
|
||
| pH Value |
5.0 - 7.5
|
||
| Ether Soluble Substances |
< 0.15 %
|
||
| Water Soluble Substances |
< 1.50 %
|
||
| Starch |
Negative
|
||
| Heavy Metals |
< 10 ppm
|
||
| Loss-on-Drying |
< 6.50 %
|
||
| Sulphated Ash/ Residue on Ignition |
< 0.30 %
|
||
| Residual Solvents |
Meets requirements of USP <467>
|
||
| Microbial Contamination |
Conforms to Ph. Eur., USP/ NF, JP
|
||
| Residual Solvents |
No residual solvents acc. Ph.Eur. 5.4.
|
||
| * Tested by: Beckmann Coulter ** Method: JRS 0401 |
|||
Applications
- Wet and Dry Granulation
- Because of their fibrous structure and good binding characteristics, ARBOCEL® M 80 and ARBOCEL® P 290 are recommended as alternatives or supplements to other fillers.
- Direct Compression
- ARBOCEL® P 290 and ARBOCEL® A 300 are recommended as inert fillers in direct compression formulations due to improved flow.
- Capsules
- ARBOCEL® A 300 is used as an inert filler and flow promoter. Excellent flow and low dusting improves handling and weight uniformity.
Benefits
- Chemically and physiologically inert
- Does not support microbial growth
- Natural fiber structure and binding properties lead to stable tablets with low friability
- 100 % plant derived
- Good compressibility
- Accelerated disintegration
- Low residual moisture content
- Well suited for sticky herbal extracts
- Pesticide-free and herbicide-free
- Free of genetically modified organisms (GMOs)
- Free of organic solvents
- Free of gluten and other allergens
- Does not contain irradiated materials nor is it irradiated in any manner during the manufacturing and packaging process
- Does not contain any additives and is not preserved, blended, flavored, colored, stabilized or diluted by any additive
Grades
| Powdered Cellulose, Ph. Eur., NF, JP, E 460(ii), FCC | |||
|---|---|---|---|
| Grade |
Average Particle Size by Laser Diffraction (µm)
|
Bulk Density (g/mL) |
Main Application
|
| ARBOCEL® M 80 |
55
|
0.20 - 0.24
|
Fine, fibrous grade, suitable for wet granulation.
|
| ARBOCEL® P 290 |
75
|
0.27 - 0.33
|
Fine grade with increased density and improved flow. Suitable for wet granulation and direct compression.
|
| ARBOCEL® A 300 |
320
|
0.31 - 0.41
|
Coarse grade with excellent flow properties used in direct compression and for capsule fillings.
|
Moisture Absorption
Compressibility
Flowability
| ARBOCEL® M 80 |
α < 62 °
|
| ARBOCEL® P 290 |
α < 49 °
|
| ARBOCEL® A 300 |
α < 36 °
|
α = angle of reprose.
Packing, Samples and Storage
Storage
Store in well closed container. Protect from excessive heat and moisture.
Packaging
Paper bag with liner 20 kg
Pallet-container
420 kg (bags)
Big Bags
1000 kg
Sample Sizes
Available in 400 g and 2 kg containers
