The Next Generation of High Functionality Excipients Turning Liquids into Tablets
Introducing PROSOLV® 730
Building on decades of excipient co-processing know-how, the newest member of the PROSOLV® family, PROSOLV® 730, was developed. It provides solutions to challenges presented by oily active ingredients and poorly water-soluble, lipophilic substances.
PROSOLV® 730 has multiple advantages for both nutraceutical and pharmaceutical formulations:
- Adsorption and direct compression of oils
- Conversion of soft-gel capsules into tablets
- Dissolution enhancement of lipophilic actives
- Modified release of lipophilic actives
What is PROSOLV® 730?
PROSOLV® 730 is a co-processed composite made from microcrystalline cellulose, silicon dioxide, and copovidone. Each component complies with the corresponding monographs of the Ph. Eur and USP/NF and is safe for nutraceutical applications.
Physical Properties of PROSOLV® 730:
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- High oil binding capacity
- White, free-flowing powder
- Chemically inert
- Non soluble
- Excellent compactability
- Enhanced lubrication efficiency
- Improved blending properties
- Over 70 times greater specific surface area than regular Microcrystalline Cellulose (MCC)
- Co-processed excipient with no chemical bonding between ingredients
How does PROSOLV® 730 Work?
Lipophilic actives have practically no solubility in water. They can be dissolved, however, in many non-aqueous media, including a wide range of different oils and organic solvents.
PROSOLV® 730 readily adsorbs and integrates oily APIs or API dissolved in non-aqueous liquids.
Oil-loaded PROSOLV® 730 is a free-flowing powder that is suitable for capsule filling as well as for direct compression of tablets.
PROSOLV® 730 quickly releases the oil in the form of a fine mist of droplets. The API partitions into the aqueous phase and becomes available for absorption.
