PROSOLV^® EASYtab SP

Introduction

The health science industry faces a wide variety of challenges including increased pressure to:

• Reduce costs
• Accelerate time to market
• Improve product performance

These challenges drive health science companies to find new solutions for improving time- and cost-efficiency in oral dosage form development and production.

Formulation scientists developing direct compression formulations generally require several conventional excipients – often at high levels – to obtain good material flow, compaction, blending properties, content uniformity, carrying capacity, stability, lubricity, and disintegration. Finding the proper excipient combinations and concentrations to achieve adequate solid dosage formulas is a time-consuming, and often expensive process, that varies with active pharmaceutical ingredient (API) characteristics.

PROSOLV EASYtab SP was developed to provide an innovative solution to meet these challenges.

PROSOLV EASYtab SP presents a set of properties that make it well-suited for continuous processing. Because it acts multi-functionally as a filler/binder, flow aid, disintegrate, and lubricant at the same time, production requires only two feeders . This not only leads to space saving, but also helps to simplify control of the production process.

PROSOLV EASYtab SP unique surface structure and good flowability enable fast and segregation-free blending with APIs. Its all-in-one structure, using sodium stearyl fumarate as a lubricant, provides outstanding robustness in terms of blending times.

Compounding with PROSOLV EASYtab SP leads to a homogeneous distribution of the individual components throughout the particle and on its surface. The synergistic effects achieved by this technology include better compactability, flowability, and content uniformity, due to a significantly increased surface area.

What is PROSOLV EASYtab SP

Using the PROSOLV technology PROSOLV EASYtab SP is the first lubricated high functionality excipient on the market. It is an all-in-one, ready-to-use excipient composite. It effectively combines four individual components.

PROSOLV EASYtab SP is a homogenous, lubricated high functionality excipient composite. Each component of the composite maintains its chemical identity while synergistically providing increased functional performance.

PROSOLV EASYtab SP Ingredients

Colloidal Silicon Dioxide (CSD)
Bulk Density 40 g/l
Average Particle Size 12 nm

Sodium Starch Glycolate (SSG)
Bulk Density 730 g/l
Average Particle Size 50 µm

Sodium Stearyl Fumarate (SSF)
Bulk Density 240 g/l
Average Particle Size 16 µm

Microcrystalline Cellulose (MCC)
Bulk Density 320 g/l
Average Particle Size 100 µm

PROSOLV EASYtab SP Compared to a Physical Blend