EMCOCEL® & VIVAPUR®

Microcrystalline Cellulose

Introduction

Microcrystalline cellulose (MCC) is an odorless, tasteless, porous white powder derived from pharmaceutical grade wood pulp. With a wide range of chemical, technical, and economic benefits, MCC is one of the most widely used binder excipients for tablet formulations.

EMCOCEL® & VIVAPUR offer:

  • High compactibility
  • Robust tablets with low friability
  • High production yields
  • Cost savings due to reduction in dosage levels
  • Compatibility with most APIs (inert)
Microcrystalline Cellulose, Ph. Eur., NF, JP, E 460(i), FCC
Air Stream Dried Quality Spray Dried Quality Average Particle Size by Laser Diffraction (µm) Bulk Density (g/mL) Main Application
VIVAPUR® EMCOCEL®
VIVAPUR® 105   15 max 0.26   Very fine grade, which gives a pleasant mouth feeling, masks bitter tastes and supports flavors
VIVAPUR® 101 EMCOCEL® 50 M 65 0.26 – 0.31 0.25 – 0.37 Fine standard MCC grade, especially suited for wet granulation, roller compaction and spheronization. Very high compactibility.
VIVAPUR® 103   65 0.26 – 0.31   Same quality as grade 101/50M, but very low moisture content (< 1.5 %) for processing water-sensitive actives.
VIVAPUR® 301   65 0.35 – 0.46   Same quality as grade 101, but increased bulk density and improved flow properties.
VIVAPUR® 102 EMCOCEL® 90 M 130 0.28 – 0.33 0.25 – 0.37 Medium size standard MCC grade, suited for the majority of directly compressible actives. Combines good flow and high compactibility.
VIVAPUR® 112 EMCOCEL® XLM 90 130 0.30 – 0.36 0.25 – 0.37 Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives
VIVAPUR® 302 EMCOCEL® HD 90 130 0.35 – 0.50 0.38 – 0.50 Same quality to grade 102/90M, but increased bulk density and improved flow properties. Especially suited for high speed tableting and processing high density actives.
VIVAPUR® 102 SCG EMCOCEL® 90 M COARSE 170/175 0.28 – 0.34 0.25 – 0.37 Coarse, DC-grade MCC.
VIVAPUR® 12   180 0.30 – 0.36   Coarse grade MCC, combines good compatibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation – even when used with low concentrations of fine actives.
VIVAPUR® 14   170 0.32 – 0.40   Same quality to grade 12, but very low moisture content (<1.5 %) for processing water-sensitive actives.
  EMCOCEL® LP 200 220   0.20 – 0.37 Coarse grade MCC, combines good compatibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation – even when used with low concentrations of fine actives.
VIVAPUR® 200   250 0.31 – 0.37   Large size MCC grade with excellent flow properties for a variety of direct compression formulations.
VIVAPUR® 200 XLM   250 0.33 – 0.40   Same quality to grades 200/LP200, but very low moisture content (<1.5 %) for processing water-sensitive actives.

Microcrystalline cellulose is one of the most widely used binder excipients for tablet formulations.