Crospovidone
Tablet disintegration involves the fast breakage of a solid dosage structure via contact with water or gastric fluids. It enables dissolution of the bio-active components as a prerequisite for achieving the desired and required bioavailability. VIVAPHARM® PVPP, Crospovidone, is unsurpassed in its performance and versatility as a superdisintegrant in formulations.
VIVAPHARM® PVPP is made up of water-insoluble synthetic crosslinked homopolymers of N-vinylpyrrolidone.
It combines different mechanisms to achieve rapid tablet disintegration at low concentrations (1-5%). Due to its viscoelasticity, VIVAPHARM® PVPP is highly compactable, resulting in robust tablets with increased tensile strength and reduced friability. Scanning electron microscope images of VIVPHARM® PVPP show a granular and porous structure with a large surface area. It enhances the dissolution of poorly soluble drug actives and due to its non-ionic property, it does not bear any risk of interaction with cationic APIs.
VIVAPHARM® PVPP
VIVAPHARM® PVPP is available in two particle sizes to serve different application requirements:
VIVAPHARM® PVPP XL
VIVAPHARM® PVPP XL-10